Endocrine Abstracts

Introduction: Testicular cancer (TC) is the most common cancer in white males aged 20–40 years, with a worldwide incidence of 7.5/100.000. Recently, we demonstrated an association between testiculopathy and alteration of the bone status, despite conserved bone-sparing effects of androgens and estrogens. Furthermore, recent published data from our group documented a strong reduction in 25(OH)D plasma levels in bilaterally orchiectomized patients compensated by testosterone...

Klinefelter syndrome (KS) was first described in 1942 and the cause for the syndrome was identified as a supernumerary X chromosome resulting in the karyotype 47,XXY. 80–90% of KS cases bear this karyotype, whereas the remaining exhibit (in decreasing frequency) varying mosaicism (e.g. 47,XXY/46,XY), carry additional sex chromosomes (48,XXXY; 48,XXYY; 49,XXXXY) or structurally abnormal X chromosomes. The prevalence of KS is up to 1 in 500 boys, and it is the most common c...